Abstract

The possibility to analyse the tumour genetic material shed in the blood is undoubtedly one of the main achievements of translational research in the latest years. In the modern clinical management of advanced non-small cell lung cancer, molecular characterisation plays an essential role. In parallel, immunotherapy is widely employed, but reliable predictive markers are not available yet. Liquid biopsy has the potential to face the two issues and to increase its role in advanced NSCLC in the next future. The aim of this review is to summarise the main clinical applications of liquid biopsy in advanced non-small cell lung cancer, underlining both its potential and limitations from a clinically driven perspective.

Details

Title
Liquid biopsy and non-small cell lung cancer: are we looking at the tip of the iceberg?
Author
Bonanno, Laura 1   VIAFID ORCID Logo  ; Dal Maso, Alessandro 2 ; Pavan, Alberto 3 ; Zulato, Elisabetta 4 ; Calvetti, Lorenzo 5 ; Pasello, Giulia 2 ; Guarneri, Valentina 2 ; Conte, PierFranco 2 ; Indraccolo, Stefano 6   VIAFID ORCID Logo 

1  Istituto Oncologico Veneto IOV—IRCCS, Medical Oncology 2, Padova, Italy (GRID:grid.419546.b) (ISNI:0000 0004 1808 1697) 
2  Istituto Oncologico Veneto IOV—IRCCS, Medical Oncology 2, Padova, Italy (GRID:grid.419546.b) (ISNI:0000 0004 1808 1697); University of Padova, Department of Surgery, Oncology and Gastroenterology, Padova, Italy (GRID:grid.5608.b) (ISNI:0000 0004 1757 3470) 
3  AULSS 3 Serenissima, Medical Oncology Department, Mestre-Venezia, Italy (GRID:grid.5608.b) 
4  Istituto Oncologico Veneto IOV—IRCCS, Basic and Translational Oncology, Padova, Italy (GRID:grid.419546.b) (ISNI:0000 0004 1808 1697) 
5  San Bortolo General Hospital, Medical Oncology Department, Vicenza, Italy (GRID:grid.411474.3) (ISNI:0000 0004 1760 2630) 
6  University of Padova, Department of Surgery, Oncology and Gastroenterology, Padova, Italy (GRID:grid.5608.b) (ISNI:0000 0004 1757 3470); Istituto Oncologico Veneto IOV—IRCCS, Basic and Translational Oncology, Padova, Italy (GRID:grid.419546.b) (ISNI:0000 0004 1808 1697) 
Pages
383-393
Publication year
2022
Publication date
Aug 2022
Publisher
Nature Publishing Group
ISSN
00070920
e-ISSN
15321827
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41416-022-01777-8
ProQuest document ID
2697205288
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.