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    Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia

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    References (65)

    • 1.

      Mutations in the kinesin-2 motor kif3b cause an autosomal-dominant ciliopathy

      B Cogne. Am. J. Hum. Genet Vol. 106, (2020): 893-904.
    • 2.

      Lineage-specific roles of hedgehog-gli signaling during mammalian kidney development

      R D’Cruz; K Stronks; CJ Rowan; ND Rosenblum. Pediatr. Nephrol Vol. 35, (2020): 725-731.
    • 3.

      Multivariate patterning of human pluripotent cells under perfusion reveals critical roles of induced paracrine factors in kidney organoid development

      NR Glass. Sci. Adv Vol. 6, (2020).
    • 4.

      Deregulation of neuro-developmental genes and primary cilium cytoskeleton anomalies in iPSC retinal sheets from human syndromic ciliopathies

      A Barabino. Stem Cell Rep Vol. 14, (2020): 357-373.
    • 5.

      Organoid single cell profiling identifies a transcriptional signature of glomerular disease

      Harder, Jennifer L; Menon, Rajasree; Otto, Edgar A; Zhou, Jian; Eddy, Sean; et al.  JCI INSIGHT Vol. 4, Iss. 1,  (Jan 2019).
    • 6.

      Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation

      A Subramanian. Nat. Commun Vol. 10, (2019).
    • 7.

      Comparative analysis and refinement of human psc-derived kidney organoid differentiation with single-cell transcriptomics

      H Wu. Cell Stem Cell Vol. 23, (2018): 869-881.e8.
    • 8.

      An actin network dispatches ciliary gpcrs into extracellular vesicles to modulate signaling

      AR Nager. Cell Vol. 168, (2017): 252-263.e14.
    • 9.

      Dynamic remodeling of membrane composition drives cell cycle through primary cilia excision

      SC Phua. Cell Vol. 168, (2017): 264-279 e215.
    • 10.

      Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease

      NM Cruz. Nat. Mater Vol. 16, (2017): 1112-1119.
    • 11.

      Gene-edited human kidney organoids reveal mechanisms of disease in podocyte development

      YK Kim. Stem Cells Vol. 35, (2017): 2366-2378.
    • 12.

      Microtubule motors drive hedgehog signaling in primary cilia

      M He; S Agbu; KV Anderson. Trends Cell Biol Vol. 27, (2017): 110-125.
    • 13.

      Nephron organoids derived from human pluripotent stem cells model kidney development and injury

      R Morizane. Nat. Biotechnol Vol. 33, (2015): 1193-1200.
    • 14.

      Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

      BS Freedman. Nat. Commun Vol. 6, (2015).
    • 15.

      Kidney organoids from human ips cells contain multiple lineages and model human nephrogenesis

      M Takasato. Nature Vol. 526, (2015): 564-568.
    • 16.

      Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells

      A Taguchi. Cell Stem Cell Vol. 14, (2014): 53-67.
    • 17.

      Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

      MI Love; W Huber; S Anders. Genome Biol Vol. 15, (2014): 1-21.
    • 18.

      Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers

      AQ Lam. J. Am. Soc. Nephrol Vol. 25, (2014): 1211-1225.
    • 19.

      Kinesin-2: a family of heterotrimeric and homodimeric motors with diverse intracellular transport functions

      JM Scholey. Annu. Rev. Cell Dev. Biol Vol. 29, (2013): 443-469.
    • 20.

      Mutations in nek8 link multiple organ dysplasia with altered hippo signalling and increased c-myc expression

      V Frank. Hum. Mol. Genet Vol. 22, (2013): 2177-2185.