Content area
Abstract
We performed a replication study in 883 Austrian multiple sclerosis (MS) patients and 972 control individuals for 25 previously risk-associated loci (39 SNPs). Two loci, rs1109670 (DDEF2/MBOAT2, p<0.02) and rs16914086 (TBC1D2, p<0.05), are replicated here for the first time. Furthermore, we tested all 39 SNPs for association with age at disease onset and measures of disease severity. We observed a trend for association of rs3135388 (HLA-DRB1*1501, p<0.01), rs7090530 (IL2RA, p<0.026) and rs1841770 (ZIC1, p<0.017) with a younger age at MS onset and of rs12044852 (CD58, p<0.035) with shorter time to reach EDSS6.[PUBLICATION ABSTRACT]
Details
Title
Replication study of multiple sclerosis (MS) susceptibility alleles and correlation of DNA-variants with disease features in a cohort of Austrian MS patients
Author
Schmied, Mascha C; Zehetmayer, Sonja; Reindl, Markus; Ehling, Rainer; Bajer-kornek, Barbara; Leutmezer, Fritz; Zebenholzer, Karin; Hotzy, Christoph; Lichtner, Peter; Meitinger, Thomas; Wichmann, H-erich; Illig, Thomas; Gieger, Christian; Huber, Klaus; Khalil, Michael; Fuchs, Sigrid; Schmidt, Helena; Auff, Eduard; Kristoferitsch, Wolfgang; Fazekas, Franz; Berger, Thomas; Vass, Karl; Zimprich, Alexander
Pages
181-7
Publication year
2012
Publication date
May 2012
ISSN
13646745
e-ISSN
13646753
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1008904354
Copyright
Springer-Verlag 2012