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A novel series of indolyl isoxazolines possessing analgesic and antiinflammatory effect were screened for antibacterial activity by using cup plate method and minimum inhibitory concentration using two fold serial dilution method. The screening results of the synthesized compounds indicated that the compounds exhibited significant antibacterial activity against gram positive and gram negative bacteria (S. aureus, B. subtilis, E. coli, P. aeruginosa). These novel Indolyl isoxazoline compounds do have the potential to develop as drug with dual anti-inflammatory and antimicrobial activity. This would be preferred from the pharmacoeconomic and patient compliance point of view.
INTRODUCTION
Bacterial infections have increased dramatically in recent years. Bacteria have been the cause of some of the most deadly diseases and wide spread epidemics in human civilization. Bacterial diseases such as tuberculosis, typhus, plague, diphtheria, typhoid fever, cholera, dysentery, and pneumonia have taken a high toll on humanity (Prabhakar et al., 1998; Meltem et al., 2006). The introduction of antibiotics in the 1940s was thought to have eliminated the scourge of all infectious diseases. However, due to the wide spread use and misuse of antibiotics, bacterial resistance to antibiotics has become a serious public health problem. With the increase in resistance of bacteria to antibiotic treatment, attention has focused on developing novel approaches to antimicrobial therapy (Oya et al., 2007; Sachin et al., 2010). A novel series of indolyl isoxazoline derivatives possess analgesic and anti-inflammatory activity. Literature survey has revealed that individually indole and isoxazoline derivatives had been shown to possess a broad spectrum of biological activities (Rani P et al., 2004; Andreani A et al., 2004 and Habeeb A. et al., 2001). Co-administration of multiple drugs for treatment of inflammatory conditions associated with microbial infection is a major risk especially in the case of patients with impaired liver or kidney functions. A single therapy of a drug with dual anti-inflammatory and antibacterial activity would be preferred from the pharmacoeconomic and patient compliance point of view. This prompted us to screen the compounds for antibacterial activity aiming at the discovery of new drug that would possess dual anti-inflammatory and antibacterial activities (Bekhit...