Abstract

Doc number: 68

Abstract

Background: The clinical importance of preoperative tumor markers remain elusive in gastric cancer. The aim of this study was to evaluate the prognostic value of AFP, CEA, CA19-9, and CA50 in T4a stage gastric cancer.

Methods: Two hundred and seventy-three T4a gastric cancer patients who underwent curative D2 gastrectomy between 1996 and 2005 were evaluated. The correlation between tumor markers and clinicopathologic characteristics and prognostic value of preoperative tumor markers were investigated.

Results: Correlation analysis showed that AFP was associated with Borrmann type (P = 0.010); CEA with sex (P = 0.029), tumors site (P = 0.014), and N stage (P = 0.001); CA19-9 with age (P = 0.047), tumor site (P = 0.011), lymphovascular invasion (P = 0.004), and N stage (P = 0.000); CA50 with age (P = 0.017), tumor site (P = 0.004), tumor size (P = 0.014), and N stage (P = 0.000). Multivariate analysis showed that the positivity of preoperative CEA, CA19-9, and CA50 were major independent poor prognostic factors of patients with T4a stage gastric cancer.

Conclusions: Preoperative serum tumor marker might be a candidate for the staging system in addition to conventional factors.

Details

Title
Prognostic significance of tumor markers in T4a gastric cancer
Author
Liu, Xiaowen; Cai, Hong; Wang, Yanong
Publication year
2012
Publication date
2012
Publisher
BioMed Central
e-ISSN
14777819
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1477-7819-10-68
ProQuest document ID
1029965523
Copyright
© 2012 Liu et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.