The AutoPulse Assisted Prehospital International Resuscitation (ASPIRE) trial investigators respond to inhomogeneity and temporal effects assertions

Abstract

The order of patient entry into the study is conflated with site because sites came on board during a period of 5 months, and the duration of the trial was only 9 months. [...]entry order is not a rigorous assessment for evaluating a learning curve. The other sites began manual CPR while getting the AutoPulse ready. [...]the change on December 28 made site C subsequently more homogenous with the other sites' approach to AutoPulse application.