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Abstract
Despite the obvious advantages (simplicity of synthesis and for mulation, low concentration, availability, and high complexing ability), a significant drawback of synthetic agents based on cationic surfactants is the low transfection efficiency. In view of this, the search for new cationic vector systems is a relevant problem. In this study, we investigated alkylammonium gemline surfactants (AGSs) with the formula R1 CH3 Br[H20001] Br[H20001] R N (CH2)m N R where m = 412, R = 3, 24, R1 = n Cn2n+ 1, where n = 10, 12, 14, and 16. The synthesized gemline surfactants with the alkylammonium head group may make a good alter native to the existing compounds to deliver genetic material into cells. The optimal conditions for transfection were established.