Behçet Hastalari ve Kontrol Grubunda Tüberkülin Deri Testi Sonuçlarinin Karsilastirilmasi/Comparison of the Results of Tuberculin Skin Test in Patients with Behçet's Disease and Control Group

Headnote

Özet

Amaç: Behçet hastalarinda hem immün sistemdeki varolan degisiklikler hem de paterji reaksiyonu nedeniyle pürifiye protein derivesi (PPD) testine yanitin Behçet hastaligi olmayanlardan farkli alinabilecegini düsünerek bu çalismayi planladik.

Gereç ve Yöntem: Bu çalismaya 19-44 yas arasi 21 Behçet hastasi dahil edildi. Bu hastalarin hiçbirisinde kolsisin disinda sistemik bir ilaç kullanimi ya da baska bir sistemik hastalik öyküsü yoktu. Tüm hastalar kolsisin tedavisi almaktaydi ve BCG asilari pozitifti. Ayni tarihlerde dermatoloji poliklinigine basvuran, tinea pedis tanisi konulan, sistemik hastalik ve sistemik ilaç kullanimi hikayesi olmayan, 19-42 yas arasi 27 gönüllü bireyden kontrol grubu olusturuldu. Tüm gönüllü bireylerde de BCG asisi pozitifti. Hem hasta hem de kontrol grubundaki tüm hastalara PPD testi yapildi.

Bulgular: Çalismamizin sonucunda Behçet hastalarinin PPD testine verdigi yanit kontrol grubuyla karsilastirildiginda anlamli derecede yüksek bulundu. PPD testine yüksek yanit verenlerin hiçbirinde aktif tüberküloz infeksiyonuna rastlanmadi.

Sonuç: PPD testinin Behçet hastalarinda yüksek bulunmasi her zaman tüberküloz infeksiyonu oldugu anlamina gelmeyip yalanci pozitiflik olarak degerlendirilebilir. (Türk derm 2012; 46: 143-6)

Anah tar Ke li me ler: Behçet hastaligi, tüberkülin deri testi, pürifiye protein derivesi

Sum mary

Background and Design: Both the alterations in the immune system and the presence of pathergy reaction in patients with Behçet's disease may lead to differences in the results of purified protein derivative (PPD) test reaction in these patients and healthy people.

Materials and Methods: Twenty-one patients with Behçet's disease aged 19-44 years old were included in this study. None of these patients were using any systemic drug (except colchicum) and had any immunosuppressive disease. All patients were under colchicum treatment and all had had BCG vaccination. Control group was formed by 27 volunteers aged 19-42 years who have applied to our dermatology outpatient clinic on the same dates and were diagnosed as tinea pedis. None of them were using any immunosuppressive drug and had any immunosuppressive disease. All of them also had had BCG vaccination. PPD test was performed to both control and patient groups.

Results: The results of PPD test were found higher in the patients with Behçet's disease compared to the control group. Active tuberculosis infection was not determined in any of the patients with increased PPD reaction.

Conclusion: Increased PPD test results in patients with Behçet's disease do not always imply tuberculosis infection...