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Cell Biochem Biophys (2012) 64:8993
DOI 10.1007/s12013-012-9375-9
ORIGINAL PAPER
Serum CRP Protein as a Differential Marker in Cancer
Hu Juan Wang Qijun Liu Junlan
Published online: 21 June 2012 Springer Science+Business Media, LLC 2012
Abstract The objective of this study was to measure the serum concentrations of C-reactive protein (CRP) in cancer patients and compare with those of immune disease patients and healthy individuals for discriminatory analysis. For this purpose, automatic systems for special protein analysis (Type: Drcon Diognostica Tarbox) was used to measure serum CRP concentrations in 276 cancer patients (Group A), 110 immune disease patients (Group B), 161 phlogistic patients (Group C), and 125 age-matched healthy individuals (Group D). Our data show that serum CRP concentrations in Group A were signicantly higher than those in Groups B and D, whereas CRP concentrations in Group B were higher than those in Group D. The differences of serum CRP concentrations between Groups A and B as well as between Groups B and D were signicant (P \ 0.01). We, therefore, concluded that the measurement of serum CRP concentrations was a fast and accurate method to distinguish between cancer and immune disease patients.
Keywords Cancer Inammation C-reactive protein
Introduction
As reported by several studies conducted in different populations, modest elevation in the plasma C-reactive protein (CRP) in the range observed in apparently healthy individuals is a strong predictor of the future vascular events [1]. Elevated plasma CRP concentrations are also
associated with an increased risk of cerebrovascular events and an increased risk of fatal and non-fatal cardiovascular events in ischemic stroke patients [2, 3].
CRP is a protein that is found in the blood and its levels can vary from person to person as well as they can vary in an individual over time. Elevated CRP levels indicate the presence of inammatory response in the body which can also put a person at higher risk for cancer. CRP is a cyclic pentamer of non-covalently bonded ve sub-units. It is synthesized by the liver cells. The CRP concentrations are low in normal, healthy individuals but in case of infection and/or inammation, its concentrations are elevated and the rate of increase in CRP concentrations correlates with the disease progression. After the use of anti-inammatory agents or after an...