Abstract

In the present study, effect of doxorubicin at 2 mg/kg b.wt. (i/p), alone, once in a wk for 4 wks and in combination with vitamin E at 250 and 500 mg/kg b.wt., orally, daily for 4 wks was evaluated on histological alterations, if any, on heart, liver, kidney, and testes of rats. Doxorubicin alone treated group showed marked congestion and degenerative changes in heart, kidney, liver, and testis. Treatment with vitamin E showed marked improvement in all the degenerative changes, though more protection was observed with the dose of 500 mg/kg.

Details

Title
A study on the toxic effects of doxorubicin on the histology of certain organs
Author
Shivakumar, P; Rani, M; Reddy, A; Anjaneyulu, Y
Pages
241-244
Publication year
2012
Publication date
Sep 2012
Publisher
Medknow Publications & Media Pvt. Ltd.
ISSN
09716580
e-ISSN
09765131
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1240975858
Copyright
Copyright Medknow Publications & Media Pvt Ltd Sep 2012