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Eur J Nutr (2013) 52:625635 DOI 10.1007/s00394-012-0366-9
ORIGINAL CONTRIBUTION
Disturbed eating at high altitude: inuence of food preferences, acute mountain sickness and satiation hormones
Isabelle Aeberli Annina Erb Kerstin Spliethoff Daniela Meier Oliver Gtze
Heiko Frhauf Mark Fox Graham S. Finlayson Max Gassmann Kaspar Berneis
Marco Maggiorini Wolfgang Langhans Thomas A. Lutz
Received: 10 January 2012 / Accepted: 24 April 2012 / Published online: 10 May 2012 Springer-Verlag 2012
AbstractPurpose Hypoxia has been shown to reduce energy intake and lead to weight loss, but the underlying mechanisms are unclear. The aim was therefore to assess changes in eating after rapid ascent to 4,559 m and to investigate to what extent hypoxia, acute mountain sickness (AMS), food preferences and satiation hormones inuence eating behavior.
Methods Participants (n = 23) were studied at near sea level (Zurich (ZH), 446 m) and on two days after rapid ascent to Capanna Margherita (MG) at 4,559 m (MG2 and MG4). Changes in appetite, food preferences and energy intake in an ad libitum meal were assessed. Plasma concentrations of cholecystokinin, peptide tyrosinetyrosine,
gastrin, glucagon and amylin were measured. Peripheral oxygen saturation (SpO2) was monitored, and AMS assessed using the Lake Louis score.
Results Energy intake from the ad libitum meal was reduced on MG2 compared to ZH (643 308 vs. 952 458 kcal, p = 0.001), but was similar to ZH on MG4 (890 298 kcal). Energy intake on all test days was correlated with hunger/satiety scores prior to the meal and AMS scores on MG2 but not with SpO2 on any of the 3 days.
Liking for high-fat foods before a meal predicted subsequent energy intake on all days. None of the satiation hormones showed signicant differences between the 3 days. Conclusion Reduced energy intake after rapid ascent to high altitude is associated with AMS severity. This effect
I. Aeberli (&) K. Berneis
Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Zurich, Ramistrasse 100, RAE B07, 8091 Zurich, Switzerlande-mail: [email protected]
I. Aeberli A. Erb
Human Nutrition Laboratory, ETH Zurich, Zurich, Switzerland
K. Spliethoff D. Meier M. Gassmann T. A. Lutz
Institute of Veterinary Physiology, Vetsuisse Faculty University of Zurich, Zurich, Switzerland
K. Spliethoff O. Gtze M. Fox M. Gassmann
K. Berneis M. Maggiorini W. Langhans T. A. Lutz
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