Cytomorphology of giant cell tumor of bone in pleural fluid

Abstract

[4] The primary and metastatic lesions usually have the same histological features of a benign tumor; however, malignant tumors with giant cells have been noted in some cases, on a retrospective review. {Figure 3} The differentials of rheumatoid arthritis, herpes viral infection, giant cell carcinoma, carcinosarcoma, mesothelioma, radiotherapy, granulomatous inflammation, and surgical intervention were considered as they have been rarely associated with the presence of giant cells in pleural effusions. Giant cell carcinoma, carcinosarcoma, and mesothelioma were excluded because of the absence of bizarre cells. [...]the clinical presentation and radiological investigations helped in ruling out all the differentials, including granulomatous inflammation.