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About the Authors:
Joseph Briggs
Contributed equally to this work with: Joseph Briggs, Melissa Paoloni
Affiliation: Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Melissa Paoloni
Contributed equally to this work with: Joseph Briggs, Melissa Paoloni
Affiliation: Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Qing-Rong Chen
Affiliation: Oncogenomics Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Xinyu Wen
Affiliation: Oncogenomics Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Javed Khan
Affiliation: Oncogenomics Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Chand Khanna
* E-mail: [email protected]
Affiliations Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Introduction
The opportunity to study health and disease in the dog (Canis lupus familiaris) has significantly expanded with the release of the first public draft of the canine genome. [1], [2], [3] This opportunity has been complemented by the development of high throughput technologies, such as expression and SNP microarrays, now commercially available for the dog [4], [5], [6]. Using these techniques and data, questions and hypotheses related to the health of dogs and their inclusion in biomedical research can now be articulated from a post-genomic perspective. [7], [8], [9] However, our ability to extend and refine our knowledge is limited due to the lack of a comprehensive functional assessment of canine gene expression in diverse sets of normal tissues. [10], [11] Rather than repeating this requisite step in new canine genomic studies, an efficient approach would be to provide researchers with an openly accessible set of validated expression profiles from canine normal tissues. A similar approach has been used for human normal organ gene expression data on both oligonucleotide and cDNA array platforms. [12],...