Abstract

Doc number: 14

Abstract: MicroRNAs (miRNAs) are evolutionarily conserved, naturally abundant, small, regulatory non-coding RNAs that inhibit gene expression at the post-transcriptional level in a sequence-specific manner. Due to involvement in a broad range of biological processes and diseases, miRNAs are now commanding considerable attention. Although much of the focus has been on the role of miRNAs in different types of cancer, recent evidence also points to a critical role of miRNAs in infectious disease, including those of bacterial origin. Now, miRNAs research is exploring rapidly as a new thrust area of biomedical research with relevance to deadly bacterial diseases like Tuberculosis (caused by Mycobacterium tuberculosis ). The purpose of this review is to highlight the current developments in area of miRNAs regulation in Mycobacterial diseases; and how this might influence the diagnosis, understanding of disease biology, control and management in the future.

Details

Title
Current understanding on micro RNAs and its regulation in response to Mycobacterial infections
Author
Singh, Pravin Kumar; Singh, Ajay Vir; Chauhan, Devendra Singh
Pages
14
Publication year
2013
Publication date
2013
Publisher
BioMed Central
ISSN
10217770
e-ISSN
14230127
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1423-0127-20-14
ProQuest document ID
1315215692
Copyright
© 2013 Singh et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.