Content area
Abstract
The hypothesis was that the daily use of a high dose of a xylitol chewing gum for 6 months would reduce the increment of decayed permanent first molar surfaces ([Delta]D^sub 6^S) in high-risk schoolchildren after 2 years.
In this randomised, clinical trial, 204 schoolchildren with a high caries risk were assigned to two experimental groups, xylitol and non-xylitol. Caries status, salivary mutans streptococci, and lactobacilli were re-evaluated 2 years later in 74 xylitol-treated and 83 non-xylitol-treated schoolchildren. Differences in mean [increment]D^sub 6^S between groups registered at baseline and at follow-up were evaluated using the nonparametric Mann-Whitney U test.
Outcome was the development of detectable carious lesions initial (D^sub 1^-D^sub 2^) and manifest (D^sub 3^) in the permanent first molars. In the xylitol group, the difference in proportion of children with decayed first permanent molars at baseline and follow-up was 1.43 % for manifest lesion and 2.86 % for initial lesions; while in the non-xylitol group was 10.26 % (p<0.01) and 16.66 % (p<0.01), respectively. A statistically significant difference regarding means was also observed in the non-xylitol group: the [increment]D^sub 6^S for manifest lesion was 0.18 (p=0.03) and 0.67 (p=0.02) for initial lesion.
The use of a chewing gum containing a high dose of xylitol for a period of 6 months has been shown to produce a long-term effect on caries development in high caries-risk children.
A school-based preventive programme based on 6 months' administration of a high dose of xylitol via chewing gum proved to be efficacious in controlling caries increment in high-risk children.[PUBLICATION ABSTRACT]