Abstract

Doc number: 17

Abstract: Exposure to urban particulate matter has been associated with an increased risk of cardiovascular disease and thrombosis. We studied the effects of transient exposure to diesel particles on fibrin clot structure of 16 healthy individuals (age 21- 44). The subjects were randomly exposed to diesel exhaust and filtered air on two separate occasions. Blood samples were collected before exposure, and 2 and 6 hours after exposure. There were no significant changes on clot permeability, maximum turbidity, lag time, fibre diameter, fibre density and fibrinogen level between samples taken after diesel exhaust exposure and samples taken after filtered air exposure. These data show that there are no prothrombotic changes in fibrin clot structure in young, healthy individuals exposed to diesel exhaust.

Details

Title
Fibrin clot structure remains unaffected in young, healthy individuals after transient exposure to diesel exhaust
Author
Metassan, Sofian; Routledge, Michael N; Lucking, Andrew J; de Willige, Shirley Uitte; Philippou, Helen; Mills, Nicholas L; Newby, David E; Ariëns, Robert AS
Pages
17
Publication year
2010
Publication date
2010
Publisher
BioMed Central
e-ISSN
1743-8977
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1743-8977-7-17
ProQuest document ID
1323887463
Copyright
© 2010 Metassan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.