Content area
Abstract
Objective
This study presents the current prevalence of mood, anxiety and personality disorders and factors associated with the existence of psychiatric disorders in patients with systemic lupus erythematosus (SLE).
Methods
The study sample was comprised of 45 patients with SLE and 60 control subjects. Mood and anxiety disorders were ascertained by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition/Clinical Version. Personality disorders were diagnosed with the Structured Clinical Interview forDSM,Revised Third EditionPersonality Disorders. The disease activity was assessed with SLE Disease Activity Index.
Results
Of the 45 patients, 21 (46.7%) had at least one mood or anxiety disorder, and 16 (35.6%) had at least one personality disorder. The most common Axis I and Axis II diagnoses in the patient group were major depression (22.2%) and obsessive-compulsive personality disorder (20.0%), respectively. Specifically, major depression, generalized anxiety disorder and obsessive-compulsive personality disorder were more prevalent in the SLE group compared to the control group. The existence of Axis I disorders was associated with a more severe disease activity of SLE.
Conclusion
Mood and anxiety disorders, particularly major depression and generalized anxiety disorder, are frequently observed in patients with SLE.