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Eur Arch Psychiatry Clin Neurosci (2013) 263:93103 DOI 10.1007/s00406-012-0322-y
ORIGINAL PAPER
Inuence of family history of major depression, bipolar disorder, and suicide on clinical features in patients with major depression and bipolar disorder
Alessandro Serretti Alberto Chiesa Raffaella Calati Sylvie Linotte Othman Sentissi
Konstantinos Papageorgiou Siegfried Kasper Joseph Zohar Diana De Ronchi
Julien Mendlewicz Daniela Amital Stuart Montgomery Daniel Souery
Received: 26 January 2012 / Accepted: 25 April 2012 / Published online: 9 May 2012 Springer-Verlag 2012
Abstract The extent to which a family history of mood disorders and suicide could impact on clinical features of patients suffering from major depression (MD) and bipolar disorder (BD) has received relatively little attention so far. The aim of the present work is, therefore, to assess the clinical implications of the presence of at least one rstand/or second-degree relative with a history of MD, BD and suicide in a large sample of patients with MD or BD. One thousand one hundred and fty-seven subjects with MD and 686 subjects with BD were recruited within the context of two large projects. The impact of a family his-
tory of MD, BD, and suicideconsidered both separately and togetheron clinical and socio-demographic variables was investigated. A family history of MD, BD, and suicide was more common in BD patients than in MD patients. A positive family history of mood disorders and/or suicide as well as a positive family history of MD and BD separately considered, but not a positive history of suicide alone, were signicantly associated with a comorbidity with several anxiety disorders and inversely associated with age of onset. The clinical implications as well as the limitations of our ndings are discussed.
Keywords Family history Major depression
Bipolar disorder Suicide
Electronic supplementary material The online version of this article (doi:http://dx.doi.org/10.1007/s00406-012-0322-y
Web End =10.1007/s00406-012-0322-y ) contains supplementary material, which is available to authorized users.
A. Serretti A. Chiesa (&) R. Calati D. De Ronchi
Institute of Psychiatry, University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy e-mail: [email protected]
A. ChiesaSection of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
S. LinotteFonds de la Recherche Scientique (FNRS), Laboratoire de Neurologie Exprimentale, Universit Libre de Bruxelles, Bruxelles, Belgium
O. SentissiDpartement de Sant Mentale et de Psychiatrie,Service...