Regulation by alternative splicing

Abstract

[...]multiple variants of a protein (isoforms) can be produced from a single gene, in a tissue- specific or developmental-stage-specific manner. Understanding the exact mechanism of action of the MBNL proteins might help to identify upstream elements of this regulatory network. [...]the epigenetic state of ES cells - that is, genomic modifications that affect gene expression without changing the DNA sequence - is subject to continuous regulation, and a link between epigenetics and alternative splicing has been proposed9,10.