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ABSTRACT:
A developed process for the synthesis of 2-ethyl phenyl hydrazine hydrochloride, a key starting material for 7-ethyl tryptophol. Starting from commercially available 2-ethylaniline. First prepared a diazonium salt of aniline by using HCl and sodium nitrite at lower temperature and then reduced the diazonium salt with sodium sulfite and Cons. H^sub 2^SO^sub 4^ within 92% yield. The method is easy, inexpensive, without purification getting pure solid. The process is very clean,high yielding & high quality and operationally simple.
KEY WORDS:7-ethyl tryptophol, 2-ethyl phenyl hydrazine hydrochloride, 2-ethyl aniline, NaNCh, water.
INTRODUCTION:
Tryptophol is a chemical compound that induces sleep in humans1. It is formed in the liver after disulfiram treatment. It is also produced by the trypanosomal parasite in sleeping sickness, tryptophol are derivatives of indole class which contain a C-3 hydroxyethyl chain 1 ' 2 . Tryptophol and its derivatives are communally extracted from various natural soures3. Some of the tryptophol derivatives exhibit biological activity4. Here 2-ethyl phenyl hydrazine hydrochloride is one of the important chemical moiety and it has a also pharmaceutical importance. 2-ethyl phenyl hydrazine hydrochloride
Etodolac is a nonsteroidal anti-inflammatory drug (NSAID)6. The U.S. Food and Drug Administration approved etodolac in January 1991. Etodolac is a non-steroidal anti- inflammatory drug (NSAID) with anti- inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis7. A recent clinical trial demonstrated that etodolac was effective in improving rear limb function in dogs with chronic osteoarthritis secondary to hip dysplasia8.
2-ethyl phenyl hydrazine hydrochloride is the key intermediate for the preparation of 7-ethyl tryptophol. Here we are prepare 2-ethyl phenyl hydrazine hydrochloride from 2-ethyl aniline with...