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About the Authors:
Mulugeta Million
* E-mail: [email protected]
Affiliations CURE/Digestive Diseases Research Center, Department of Medicine, Division of Digestive Diseases, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, Oppenheimer Family Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, VA Greater Los Angeles Healthcare System, Los Angeles, California, United States of America
Jing-Fang Zhao
Affiliations CURE/Digestive Diseases Research Center, Department of Medicine, Division of Digestive Diseases, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, VA Greater Los Angeles Healthcare System, Los Angeles, California, United States of America
Andrew Luckey
Affiliations CURE/Digestive Diseases Research Center, Department of Medicine, Division of Digestive Diseases, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, VA Greater Los Angeles Healthcare System, Los Angeles, California, United States of America
József Czimmer
Affiliations CURE/Digestive Diseases Research Center, Department of Medicine, Division of Digestive Diseases, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, VA Greater Los Angeles Healthcare System, Los Angeles, California, United States of America
George D. Maynard
Affiliation: Neurogen Corporation, Branford, Connecticut, United States of America
John Kehne
Affiliation: Neurogen Corporation, Branford, Connecticut, United States of America
Diane C. Hoffman
Affiliation: Neurogen Corporation, Branford, Connecticut, United States of America
Yvette Taché
Affiliations CURE/Digestive Diseases Research Center, Department of Medicine, Division of Digestive Diseases, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, Oppenheimer Family Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, The David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, VA Greater Los Angeles Healthcare System, Los Angeles, California, United States of America
Introduction
Corticotropin releasing factor (CRF), a 41-amino acid peptide originally isolated from ovine brain extract, is the principal mediator of the hypothalamic-pituitary-adrenal (HPA) stress–response [1], [2] CRF exerts its biological functions by activating two classes of B subfamily G-protein coupled receptors, CRF1 and CRF2 receptors...