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ABSTRACT:
Amino-indane is an important structural moiety found in numerous pharmaceutically active compounds. Amino-indane has non-heterocyclic fused ring having six member benzene ring and five member cyclopentane ring with amino group. Amino-indane derivatives play a vital role in the field of medicinal chemistry. This has the important place to synthesis of class of different pharmacological activities. Amino-indane moiety is an important pharmacophore and exhibits outstanding biological activities. A number indane derivatives have acquired a special place in heterocyclic field because of their diversified activities such as antimicrobial, antipyretic, analgesic, anticonvulsant, CNS Depressant anti-inflammatory, anticancer activity. This review emphasized the recent researches in amino-indanes in various diseases and disorders.
KEYWORDS: Indane, Amino-indane, Anti-inflammatory, Pharmacological activity.
INTRODUCTION:
Indane or Indan is a hydrocarbon petrochemical compound, with formula C9H10. It is non-heterocyclic compound in which five member ring fused with six member benzene ring. Indane derivatives include compounds such as 1-methyl-indane and 2-methyl-indane (where one methyl group is attached to the five carbon ring), 4-methyl-indane and 5-methyl-indane (where one methyl group is attached to the benzene ring), various dimethyl-indanes, 1-amino-indane, 2-amino-indane (where amino group attached to the five carbon ring) and various pharmaceutical derivatives. Indane can also be converted in a catalytic reactor to other aromatics such as xylene. 1
Amino indane is one of the derivatives of indane. It is research chemical with stimulant properties. 2-Amino-indane and 1-Amino-indane are position isomers, in which amino functional group is attached to five membered carbon ring. 2 Since 1960 various compounds are start to synthesize from amino-indane. Amino-indane has various pharmacological activities like
Anti-inflammatory,3 Analgesic,4 Antipyretic,5 Anticonvulsant,6 Anti-leukemic,7 Anti-Parkinson, 8 Anti-viral, 9 Anti-Microbial,10 Anticancer,11 Ion channel inhibitor,12 Protein kinase inhibitor,13 Biologically active peptide,14 Photo labeling agent,15 Amino peptidase inhibitor,16 Anti-Thrombin,17 Pharmacologically active Chiral ligand,18 Tachykinin mimetic,19 Psychotropic agent.20 In the present review, novel amino-indane derivatives were discussed having following class of biological activities.
Anti-inflammatory agents
Frankish Neil et al synthesized 3-(substituted amino)-inden-1-one and evaluated for anti-inflammatory activity. The activity of indanone derivative increases with electronegative substitution on amino group. From all novel compound 3-(N-cyclopentyl-N-methyl amino)-inden-1-one (1) has more potent anti-inflammatory activity.3
Barlow JW et al synthesized a novel dimeric 1,2,3,4-tetrahydro-naphthalenylamine and indan-1-ylamine derivatives and evaluated for mast cell-stabilizing and anti-allergic activity. Among that compound (2) exhibited potent mast...