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ABSTRACT:
A developed process for the synthesis of tryptophol a key starting material for Indoramin. Starting from commercially available indole. Firstly prepared (lH-indol-3yl)-oxo-acetyl chloride from indole by using oxalyl chloride and then prepared ethyl ester by using ethanol. Ethyl ester reduced by sodium borohydride and getting pure tryptophol without purification within 92% yield, the method is easy, inexpensive , without purification getting pure solid. The process is very clean, high yielding & high quality and operationally simple.
KEY WORDS: indole, (lH-indol-3yl)-oxo-acetyl chloride,(lH-indol-3-yl)oxo-acetic acid ethyl ester, tryptophol, oxalyl chloride, indoramin.
INTRODUCTION:
Tryptophol is a chemical compound that induces sleep in humans1. It is formed in the liver after disulfiram treatment. It is also produced by the trypanosomal parasite in sleeping sickness, tryptophol are derivatives of indole class which contain a C-3 1 2 hydroxyethyl chain ' . Tryptophol and its derivatives are communally extracted from various natural souresT Some of the tryptophol derivatives exhibit biological activity4. Here tryptophol is one of the important chemical moiety and it has a also pharmaceutical importance. Tryptophol was prepared from indole . Tryptophol mainly used for the synthesis of Indoramin.
Indoramin hydrochloride works by blocking alpha receptors in certain areas of the body. Alpha receptors are found on the muscle in the prostate gland. This gland is found only in men and lies at the top of the tube connecting the bladder to the outside (urethra). The prostate gland often enlarges with advancing age (a condition called benign prostatic hyperplasia), pressing on the urethra and obstructing the flow of urine from the bladder. This can cause various urinary symptoms such as difficulty passing urine. By blocking the alpha receptors in the prostate gland, indoramin causes the muscle in the prostate gland to relax. This allows urine to flow freely past the prostate and relieves the urinary symptoms of this condition.
Indoramin (trade names Baratol and Doralese) is a piperidine antiadrenergic agent. It is an alpha-1 selective adrenoceptor antagonist5 with direct myocardial depression action;...