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OBES SURG (2014) 24:184190 DOI 10.1007/s11695-013-1084-y
ORIGINAL CONTRIBUTIONS
Changes in Intestinal Permeability after Roux-en-Y Gastric Bypass
Alexandre Lages Savassi-Rocha & Marco Tlio Costa Diniz & Eduardo Garcia Vilela &
Maria de Ftima Haueisen Sander Diniz & Soraya Rodrigues de Almeida Sanches &
Alosio Sales da Cunha & Maria de Lourdes de Abreu Ferrari &
Henrique Oswaldo da Gama Torres & Bruno Antonio Maciente &
Gabriela Santana Ataliba & Paloma Maciel Arajo &
Taciana Bretas Guerra & Inara Kellen Fonseca Balbino
Published online: 8 October 2013# Springer Science+Business Media New York 2013
AbstractBackground Roux-en-Y gastric bypass (RYGB) interferes considerably with the anatomy and physiology of the gastrointestinal tract. The study of intestinal permeability can provide important information regarding changes in the structure and function of the mucosal barrier after the procedure. Methods The urinary excretion rates of lactulose and mannitol after oral intake of both substances were evaluated. We also
evaluated the lactulose/mannitol excretion ratio. Tests were performed during the preoperative period (T0), at the first postoperative month (T1), and at the sixth postoperative month (T6).
Results The study included 16 morbidly obese patients. The excretion rate of mannitol was significantly lower at T1 compared with T0 and T6 (p =0.003). There was no significant difference in the excretion rates of lactulose or in the lactulose/
A. L. Savassi-Rocha (*) : M. T. C. Diniz : E. G. Vilela :
S. R. d. A. Sanches : A. S. da Cunha : M. d. L. d. A. Ferrari Instituto Alfa de Gastroenterologia, Hospital das Clnicas, Universidade Federal de Minas Gerais, Avenida Bernardo Monteiro, 1397/802, 30150-281 Belo Horizonte, Minas Gerais, Brazile-mail: [email protected]
M. T. C. Dinize-mail: [email protected]
E. G. Vilelae-mail: [email protected]
S. R. d. A. Sanchese-mail: [email protected]
A. S. da Cunhae-mail: [email protected]
M. d. L. d. A. Ferrarie-mail: [email protected]
E. G. Vilela : M. d. F. H. S. Diniz : A. S. da Cunha :
M. d. L. d. A. Ferrari : H. O. d. G. TorresDepartamento de Clnica Mdica, Faculdade de Medicina e Hospital das Clnicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
M. d. F. H. S. Dinize-mail: [email protected]
H. O. d. G. Torrese-mail: [email protected]
M. T. C. Diniz : S. R. d. A. SanchesDepartamento de Cirurgia, Faculdade de Medicina, Universidade Federal...