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About the Authors:
Weg M. Ongkeko
Contributed equally to this work with: Weg M. Ongkeko, Doug Burton, Alan Kiang, Eric Abhold, Selena Z. Kuo
* E-mail: [email protected]
Affiliation: Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego, La Jolla, California, United States of America
Doug Burton
Contributed equally to this work with: Weg M. Ongkeko, Doug Burton, Alan Kiang, Eric Abhold, Selena Z. Kuo
Affiliation: Department of Medicine, Veterans Administration San Diego Healthcare System, University of California San Diego, La Jolla, California, United States of America
Alan Kiang
Contributed equally to this work with: Weg M. Ongkeko, Doug Burton, Alan Kiang, Eric Abhold, Selena Z. Kuo
Affiliation: Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego, La Jolla, California, United States of America
Eric Abhold
Contributed equally to this work with: Weg M. Ongkeko, Doug Burton, Alan Kiang, Eric Abhold, Selena Z. Kuo
Affiliation: Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego, La Jolla, California, United States of America
Selena Z. Kuo
Contributed equally to this work with: Weg M. Ongkeko, Doug Burton, Alan Kiang, Eric Abhold, Selena Z. Kuo
Affiliation: Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego, La Jolla, California, United States of America
Elham Rahimy
Affiliation: Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego, La Jolla, California, United States of America
Meng Yang
Affiliation: AntiCancer, Inc., San Diego, California, United States of America
Robert M. Hoffman
Affiliation: AntiCancer, Inc., San Diego, California, United States of America
Jessica Wang-Rodriguez
Affiliation: Department of Pathology, University of California San Diego and the Veterans Administration San Diego Healthcare System, San Diego, California, United States of America
Leonard J. Deftos
Affiliation: Department of Medicine, Veterans Administration San Diego Healthcare System, University of California San Diego, La Jolla, California, United States of America
Introduction
Parathyroid hormone-related protein (PTHrP) possesses a variety of physiological and developmental functions but is also known to facilitate the progression of many cancers including prostate cancer. We and others have previously shown that PTHrP stimulates prostate cancer cell growth, invasion and metastasis, operating via both paracrine/autocrine and intracrine pathways [1]–[3]. PTHrP is known to activate a...