Comparison of automated atlas-based striatal segmentation in application to the study of amphetamine induced displacement of [11C] raclopride

Abstract

[...]reliable automated methods with low bias are sought for convenience and reduction of data processing time. ROI SPM results FDS results Avs 19.8±5.9 5.4±5.0 Dca 8.6±2.9 7.5±3.6 Mca 6.8±2.2 3.6±1.8 Dpu 4.6±4.0 4.9±3.6 Vpu 19.8±8.9 8.7±7.4 Table 1 Absolute % difference in BP from hand-drawn ROI analysis ROI % Change manual % Change SPM % Change FDS Avs -11.6±4.8 -12.7±2.9 -11.2±4.8 Dca -12.8±5.3 -12.8±3.1 -13.0±6.1 Mca -10.9±4.5 -10.7±3.8 -11.2±4.9 Dpu -20.7±3.6 -22.6±3.3 -21.1±4.9 Vpu -20.3±3.9 -20.2±1.8 -17.9±5.6 Table 2 % Change in BP from pre- to post-AMPH administration