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Eur J Epidemiol (2014) 29:7988 DOI 10.1007/s10654-013-9876-x
META-ANALYSIS
Dietary ber intake and risk of type 2 diabetes: a doseresponse analysis of prospective studies
Baodong Yao Hong Fang Wanghong Xu
Yujie Yan Huilin Xu Yinan Liu
Miao Mo Hua Zhang Yanping Zhao
Received: 4 July 2013 / Accepted: 27 December 2013 / Published online: 5 January 2014 Springer Science+Business Media Dordrecht 2014
Abstract Observational studies suggest an association between dietary ber intake and risk of type 2 diabetes, but the results are inconclusive. We conducted a meta-analysis of prospective studies evaluating the associations of dietary ber intake and risk of type 2 diabetes. Relevant studies were identied by searching EMBASE (from 1974 to April 2013) and PubMed (from 1966 to April 2013). The xed or random-effect model was selected based on the homogeneity test among studies. In addition, a 2-stage random-effects doseresponse meta-analysis was performed. We identied 17 prospective cohort studies of dietary ber intake and risk of type 2 diabetes involving 19,033 cases and 488,293 participants. The combined RR (95 % CI) of type 2 diabetes for intake of total dietary ber, cereal ber, fruit ber and insoluble ber was 0.81 (0.730.90), 0.77 (0.690.85), 0.94(0.880.99) and 0.75 (0.630.89), respectively. A nonlinear relationship was found of total dietary ber intake with risk of type 2 diabetes (Pfor nonlinearity \ 0.01), and the RRs (95 %
CI) of type 2 diabetes were 0.98 (0.901.06), 0.97(0.871.07), 0.89 (0.800.99), 0.76 (0.650.88), and 0.66(0.530.82) for 15, 20, 25, 30, and 35 g/day. The departure from nonlinear relationship was not signicant (Pfor nonlinearity = 0.72), and the risk of type 2 diabetes decreased by 6 % (RR 0.94, 95 % CI 0.930.96) for 2 g/day increment in
cereal ber intake. Findings from this meta-analysis indicate that the intakes of dietary ber may be inversely associated with risk of type 2 diabetes.
Keywords Dietary ber Type 2 diabetes Prospective
studies Meta-analysis
Introduction
Diabetes mellitus are rising globally becoming one of the major non-communicable diseases [1]. It was estimated the number of people with diabetes increased from 153 (127182) million in 1980, to 347 (314382) million in 2008 globally [1].Type 2 diabetes causes substantial morbidity and mortality in those affected and is associated with enormous health care costs [2, 3]. And in Germany...