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Estimating the advantages and disadvantages of Matlab/Simulink, Visual Basic (VB) and AutoCAD software, the model of the working process of internal combustion (IC) engine was built based on Matlab/Simulink, and the drawing programs for engine structure were written with the parametric design language AutoLISP. A user-friendly VB interface of inputting parameter was established, realizing VB coupled with AutoCAD and Matlab/Simulink software. Calling the AutoLISP drawing program nested in the AutoCAD and Matlab/Simulink software via VB, integration of the simulation and analysis of the engine and the CAD drawing of its body can be achieved. Its more efficient to analyze the performance and optimize the structure parameters of engines.