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Abstract
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A practical approach for the preparation of (......) 5-ylidene rhodanine derivatives bearing the (4,5-dihalogeno-pyrrol-2-yl)carbamoyl fragment of dispacamide A is reported. The new compounds were obtained in good yields (19-88 %) by Knoevenagel condensation according to a solution-phase microwave dielectric heating protocol in the presence of organic bases (piperidine, TEA, and AcONa) from a set of ......-substituted rhodanines 2(a-i). The ten synthetic products 3(a-j) have been synthesized with a ......-geometry about their exocyclic double bond and the structure of one of these compounds (3) was confirmed by a single X-ray diffraction analysis. The new (......) 5-ylidene rhodanine derivatives 3(a-j) were tested against eight protein kinases.
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