Multiple intracranial tumors: Coexistence of a glioblastoma and null cell pituitary adenoma within the same patient

Abstract

In our case the immune markers for the nuclear p53 oncoprotein were positive. Besides overexpression and amplification, in GBM there are also mutations at the signal transduction pathways of platelet derived growth factor, vascular endothelial growth factor, transforming growth factor [alpha]/β, hepatocyte growth factor and epidermal growth factor. In our patient the immune markers for PTEN and mutated IDH1/2 were negative in the GBM specimen, implicating a poor prognosis. Besides those molecular aberrations in the signaling pathways of gliomas, there also common gene mutations in pituitary adenomas like Cyclin D1, pituitary tumor transforming gene, EGFR and p16.