Abstract

Doc number: 87

Abstract

Background: A possible role of oxidative stress in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis has been suggested. The detoxification enzyme NAD(P)H dehydrogenase, quinone 1 (NQO1) has been found up-regulated in MS lesions. A previous report described an association between the SNP rs1800566 in the NQO1 gene and the risk for MS in the Greek population. The aim of this study was to replicate a possible influence of the. SNP rs1800566 in the NQO1 gene in the risk for MS in the Spanish Caucasian population.

Methods: We analyzed allelic and genotypic frequency of NQO1 rs1800566 in 290 patients with MS and 310 healthy controls, using TaqMan Assays.

Results: NQO1 rs1800566 allelic and genotypic frequencies did not differ significantly between MS patients and controls, and were unrelated with age of onset of MS, gender, and clinical type of MS.

Conclusions: Our results indicate that NQO1 rs1800566 does not have an effect on MS disease risk.

Details

Title
NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis
Author
Agúndez, José A G; García-Martín, Elena; Martínez, Carmen; Benito-León, Julián; Millán-Pascual, Jorge; Calleja, Patricia; Díaz-Sánchez, María; Pisa, Diana; Turpín-Fenoll, Laura; Alonso-Navarro, Hortensia; Ayuso-Peralta, Lucía; Torrecillas, Dolores; Plaza-Nieto, José Francisco; Jiménez-Jiménez, Félix Javier
Pages
87
Publication year
2014
Publication date
2014
Publisher
Springer Nature B.V.
e-ISSN
14712377
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1471-2377-14-87
ProQuest document ID
1519086353
Copyright
© 2014 Agúndez et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.