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Copyright Korean Society of Pathologists, Korean Society for Cytopathology Apr 2014

Abstract

Primary effusion lymphoma (PEL) is a human herpes virus 8 (HHV8)-positive large B-cell neoplasm that presents as an effusion with no detectable tumor in individuals with human immunodeficiency virus infection or other immune deficiencies. PEL is an aggressive neoplasm with a poor prognosis. PEL cells show diverse morphologies, ranging from immunoblastic or plasmablastic to anaplastic. The immunophenotype of PEL is distinct, but its lineage can be misdiagnosed if not assessed thoroughly. PEL cells usually express CD45, lack B- and T-cell-associated antigens, and characteristically express lymphocyte activation antigens and plasma cell-associated antigens. Diagnosis of PEL often requires the demonstration of a B-cell genotype. HHV8 must be detected in cells to diagnose PEL. In most cases, PEL cells also harbor the Epstein-Barr virus (EBV) genome. Similar conditions associated with HHV8 but not effusion-based are called "extracavitary PELs." PELs should be differentiated from HHV8-negative, EBV-positive, body cavity-based lymphomas in patients with long-standing chronic inflammation; the latter can occur in tuberculous pleuritis, artificial pneumothorax, chronic liver disease and various other conditions. Despite their morphological similarity, these various lymphomas require different therapeutic strategies and have different prognostic implications. Correct diagnosis is essential to manage and predict the outcome of patients with PEL and related disorders. [PUBLICATION ABSTRACT]

Details

Title
Current Concepts in Primary Effusion Lymphoma and Other Effusion-Based Lymphomas
Author
Kim, Yoonjung; Park, Chan Jeong; Roh, Jin; Huh, Jooryung
Pages
81-90
Section
REVIEW
Publication year
2014
Publication date
Apr 2014
Publisher
Korean Society of Pathologists, Korean Society for Cytopathology
ISSN
17381843
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1528101474
Copyright
Copyright Korean Society of Pathologists, Korean Society for Cytopathology Apr 2014