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About the Authors:
Sanjay Swaminathan
Affiliations Applied and Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America, Department of Clinical Immunology, Western Sydney Local Health District, Sydney, Australia, Sydney Medical School, University of Sydney, Sydney, Australia, School of Medicine, University of Western Sydney, Sydney, Australia
Zonghui Hu
Affiliation: Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Adam W. Rupert
Affiliation: Applied and Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
Jeanette M. Higgins
Affiliation: Applied and Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
Robin L. Dewar
Affiliation: Applied and Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
Randy Stevens
Affiliation: Applied and Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
Qian Chen
Affiliation: Applied and Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
Catherine A. Rehm
Affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Julia A. Metcalf
Affiliation: Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Michael W. Baseler
Affiliation: Applied and Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
H. Clifford Lane
Affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Tomozumi Imamichi
* E-mail: [email protected]
Affiliation: Applied and Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
Introduction
Interleukin-27 (IL-27) has emerged as an important immunomodulatory cytokine playing pivotal roles in both innate and adaptive immunity. IL-27 is composed of a p28 subunit and an Epstein-Barr virus induced gene 3 (EBI3) subunit [1] and is produced mostly in antigen presenting cells upon stimulation. Binding of IL-27...