Content area

Abstract

Recent neuroimaging studies have demonstrated that human brain networks have economic small-world topology and modular organization, enabling efficient information transfer among brain regions. However, it remains largely unknown how the small-world topology and modular organization of human brain networks emerge and develop. Using longitudinal MRI data of 28 healthy pediatric subjects, collected at their ages of 1month, 1year, and 2years, we analyzed development patterns of brain anatomical networks derived from morphological correlations of brain regional volumes. The results show that the brain network of 1-month-olds has the characteristically economic small-world topology and nonrandom modular organization. The network's cost efficiency increases with the brain development to 1year and 2years, so does the modularity, providing supportive evidence for the hypothesis that the small-world topology and the modular organization of brain networks are established during early brain development to support rapid synchronization and information transfer with minimal rewiring cost, as well as to balance between local processing and global integration of information.

Details

Identifier / keyword
Title
Brain anatomical networks in early human brain development
Publication title
NeuroImage; Amsterdam
Volume
54
Issue
3
Pages
1862-71
Publication year
2011
Publication date
Feb 1, 2011
Publisher
Elsevier Limited
Place of publication
Amsterdam
Country of publication
United Kingdom
ISSN
10538119
e-ISSN
10959572
Source type
Scholarly Journal
Language of publication
English
Document type
Journal Article
Accession number
20650319
ProQuest document ID
1549923988
Document URL
https://www.proquest.com/scholarly-journals/brain-anatomical-networks-early-human-development/docview/1549923988/se-2?accountid=208611
Copyright
Copyright Elsevier Limited Feb 1, 2011
Last updated
2024-03-21
Database
ProQuest One Academic