Content area
Full text
ABSTRACT:
The aim of this work, synthesis of heterocycles included more than one hetero atom like (N, S, O) to produce various cycles [3-8] membered ring. This work involved five parts, included synthesis of compounds [1-20] first part includes synthesis of three compounds [1,11,17] through reaction between 4-alimethyl amino benzaldehyde with different primary aromatic amines to give (schiffbases ), second part involved synthesis of compounds [2, 1218, 20] from reaction between schiffbases with (maliec anhydride m, cystiene, 3,5dinitro salcylic acid , 0-thiol benzoic acid, alanine ) to give (oxazepine, imidazolidine, oxazine ) third part synthesis of diazepine compounds [3-5] from reaction between oxazepine with (hydro guandine, thiosimecarbazide, thiourea ) four part involved synthesis of compounds [6- 10] from reaction between Diazepine with (di chloro methane, benzoic acid, oxalic acid, di chloro ethane ) to give (three, four, five) rings, five part involved of compounds [13-16] from reaction between five membered with (phthalic anhydride, malic anhydride, oxalic acid, dichloro ethane) to give (three, five, six, eight), six part include: study of chromatography.
The structure of these compounds were characterized by (H.NMR, FI.IR, C.H.N) -techniques and their melting points, then study of chromatography behavior.
KEYWORDS: Oxazepine, diazepine, maziridine, schiffbase, melamine, four membered, eight membered
INTRODUCTION:
Heterocyclic compounds used to develop of biological or medicinal interest to chemists (1). The compounds generally consist of (5,6,7-membered) saturated at unsaturated cycles of more than one hetero atom which may be similar or dissimilar(2). The aromatic-hetero cyclic polymers are one of versatile and widely utilized class of organic polymers, they are used in several applications(3) . oxazepine refers to any seven-membered ring containing au oxygen and nitrogen atom(4), synthesis of these compounds in this work is a class of pericyclic reaction which is classified as a (5+2=7), implying5-atom component plus 2- atom component leading to 7- membered cyring(5). Oxazepinederivative is used as an antibiotic, enzyme inhibitor, pharmacological interest (6) and have dical and biological important(7).
Chemical compounds built on a diazepines fold have recently emerged as potent inhibitors of theacetyllysine binding activity of bromodomain-containing proteins, which is required for gene transcriptional activation in cancer and inflammation(8). Diazepine derivatives are used as tranquilizers, anticonvulsant, anxiolytic, analgesics, sedatives, anti depressives and hypnotic agents. Diazepine continues. To be challenging end ever in...