Aging is a simple deprivation syndrome driven by a quasi-programmed preventable and reversible drift of control system set points due to inappropriate organism-environment interaction

ISSN 0006 2979, Biochemistry (Moscow), 2014, Vol. 79, No. 10, pp. 1133 1135. Pleiades Publishing, Ltd., 2014.

Original Russian Text A. V. Khalyavkin, V. N. Krutko, 2014, published in Biokhimiya, 2014, Vol. 79, No. 10, pp. 1392 1395.

REVIEW

Aging Is a Simple Deprivation SyndromeDriven by a Quasi programmed Preventableand Reversible Drift of Control System Set Points Due to Inappropriate OrganismEnvironment Interaction

A. V. Khalyavkin1,2* and V. N. Krutko2

1Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russia; fax: [phone]; E mail: [email protected]

2Institute for Systems Analysis, Russian Academy of Sciences, 117312 Moscow, Russia; fax: [phone]; E mail: [email protected]

Received July 14, 2014

AbstractThere are two well known but opposing concepts of the reason for aging. The first supposes that senescence is pro grammed similarly to the genetic program of development from a zygote up to a mature organism. Genetically determined senile wasting is thought to be associated with the necessity to renovate the population to ensure its adaptation and survival. According to the concept of the stochastic aging (due to accumulation of occasional error and damage), there is no built in program of aging. There is only a program of development up to the state of maturity, and then the organism should be able to maintain itself limitlessly. However, although the efficiency of repair systems is assumed to be rather high, it is less than 100%. Just this has to result in aging because of accumulation of various errors. We have continued and developed another approach that con siders both programmed and stochastic concepts to be incorrect. Aging is a simple deprivation syndrome driven by preventable and even reversible drifts of control systems set points because of an inappropriate organismenvironment interaction.

DOI: 10.1134/S0006297914100150

Key words: plasticity of aging, environmental influences, cause of aging, retardation of senescence, self maintenance, reversibility of aging

According to data of the World Health Organization, the rate of human aging depends 10% on the living stan dard, 20% on the genotype, 20% on the environment, and 50% on way of living. Thus, ecological factors and activities induced by them significantly influencing the way of living are the major contributors to the genetic potential of longevity. It is known that only less than 5%...