Abstract

Doc number: 208

Abstract

Background: Seizures are one of the most important neurologic complications of human immuno-deficiency virus (HIV)-negative cryptococcal meningitis. A better understanding of the risk associated factors can help predict those who will require treatment.

Methods: This 22-year retrospective study enrolled 180 patients. Prognostic variables independently associated with seizures or fatality were analyzed using stepwise logistic regression.

Results: Twenty-eight patients with HIV-negative cryptococcal meningitis had seizures, including 13 with early seizures and 15 with late seizures. The mean time interval from HIV-negative cryptococcal meningitis to first seizure in the early and late seizure groups were 1.5 and 51.4 days, respectively. Nine out of the 28 cases (32%) occurred within 24 hours of presentation. The overall mortality rate was 54% (15/28) and two patients progressed to epilepsy.

Conclusions: Patients with seizure have worse outcomes and longer hospitalization. Most first seizures occur within one year after the diagnosis of HIV-negative cryptococcal meningitis.

Details

Title
Predictors and long-term outcome of seizures in human immuno-deficiency virus (HIV)-negative cryptococcal meningitis
Author
Hung, Chih-Wei; Chang, Wen-Neng; Kung, Chia-Te; Tsai, Nai-Wen; Wang, Hung-Chen; Lin, Wei-Che; Huang, Chi-Ren; Huang, Chih-Cheng; Tsai, Wan-Chen; Chang, Hsueh-Wen; Su, Yu-Jih; Lin, Yu-Jun; Cheng, Ben-Chung; Chang, Ya-Ting; Su, Chih-Min; Lu, Cheng-Hsien
Pages
208
Publication year
2014
Publication date
2014
Publisher
BioMed Central
e-ISSN
14712377
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s12883-014-0208-x
ProQuest document ID
1614555247
Copyright
© 2014 Hung et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.