Amlodipine/bisoprolol/captopril overdose: Multi-drug intoxication leading to acute heart failure and multiple organ failure: case report

A 17-year-old woman developed multi-drug intoxication leading to acute heart failure and multiple organ failure following an overdose of captopril, bisoprolol and amlodipine in a suicide attempt.

The woman presented 7 hours after an ingestion of captopril 875mg, bisoprolol 125mg, amlodipine 600 mg in a suicide attempt. She was admitted to an ICU in a moderately severe condition. She was noted to have abdominal pain, dizziness and weakness. Physical examination revealed a BP of 60/40mm Hg, a HR of 40/min and hypothermia. Her skin was moist and cold. She had shallow and fast breathing, significantly longer capillary flow time, peripheral cyanosis and anuria. Tests revealed metabolic acidosis and...