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Nature Reviews Molecular Cell Biology | AOP, published online 26 March 2014; doi:10.1038/nrm3784
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CONSERVATIVE DNA REPLICATION
The classic experiment described by Meselson and Stahl in their paper from 1958 demonstrated that genomes are replicated in a semiconservative manner. However, Donnianni and Symington, and Sainiet al. have recently provided examples of conservative DNA replication in yeastcells.
DNA replication initiated from origins of replication proceeds in a semiconservative manner, such that each new copy of double-stranded DNA contains one original strand and one newly replicated strand (Meselson and Stahl). However, DNA replication canalso be initiated, after DNA replication fork collapse, by break-induced replication (BIR; also known as recombination-restarted replication), as discussed by Anand and colleagues.
In BIR,...