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© 2015 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Since being domesticated about 10,000–12,000 years ago, domestic pigs (Sus scrofa domesticus) have been selected for traits of economic importance, in particular large body size. However, Yucatan miniature pigs have been selected for small body size to withstand high temperature environment and for laboratory use. This renders the Yucatan miniature pig a valuable model for understanding the evolution of body size. We investigate the genetic signature for selection of body size in the Yucatan miniature pig. Phylogenetic distance of Yucatan miniature pig was compared to other large swine breeds (Yorkshire, Landrace, Duroc and wild boar). By estimating the XP-EHH statistic using re-sequencing data derived from 70 pigs, we were able to unravel the signatures of selection of body size. We found that both selections at the level of organism, and at the cellular level have occurred. Selection at the higher levels include feed intake, regulation of body weight and increase in mass while selection at the molecular level includes cell cycle and cell proliferation. Positively selected genes probed by XP-EHH may provide insight into the docile character and innate immunity as well as body size of Yucatan miniature pig.

Details

Title
Exploring the Genetic Signature of Body Size in Yucatan Miniature Pig
Author
Kim, Hyeongmin; Ki Duk Song; Hyeon Jeong Kim; Park, WonCheoul; Kim, Jaemin; Lee, Taeheon; Dong-Hyun, Shin; Kwak, Woori; Young-jun, Kwon; Sung, Samsun; Moon, Sunjin; Kyung-Tai, Lee; Kim, Namshin; Hong, Joon Ki; Eo, Kyung Yeon; Seo, Kang Seok; Girak Kim; Park, Sungmoo; Cheol-Heui Yun; Kim, Hyunil; Choi, Kimyung; Kim, Jiho; Lee, Woon Kyu; Duk-Kyung, Kim; Jae-Don Oh; Eui-Soo, Kim; Cho, Seoae; Lee, Hak-Kyo; Kim, Tae-Hun; Kim, Heebal
First page
e0121732
Section
Research Article
Publication year
2015
Publication date
Apr 2015
Publisher
Public Library of Science
e-ISSN
19326203
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1673954085
Copyright
© 2015 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.