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Web End = Environ Health Prev Med (2015) 20:347353 DOI 10.1007/s12199-015-0473-3
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Web End = The relationship between body mass index and uric acid: a study on Japanese adult twins
Kentaro Tanaka1 Soshiro Ogata2 Haruka Tanaka2,3 Kayoko Omura3
Chika Honda4 Osaka Twin Research Group Kazuo Hayakawa3
Received: 20 March 2015 / Accepted: 24 May 2015 / Published online: 3 June 2015 The Japanese Society for Hygiene 2015
AbstractObjectives The present study aimed to investigate the association between body mass index (BMI) and uric acid (UA) using the twin study methodology to adjust for genetic factors.
Methods The association between BMI and UA was investigated in a cross-sectional study using data from both monozygotic and dizygotic twins registered at the Osaka University Center for Twin Research and the Osaka University Graduate School of Medicine. From January 2011 to March 2014, 422 individuals participated in the health examination. We measured height, weight, age, BMI, lifestyle habits (Breslows Health Practice Index), serum UA, and serum creatinine. To investigate the association between UA and BMI with adjustment for the clustering of a twin within a pair, individual-level analyses were performed using generalized linear mixed models (GLMMs). To investigate an association with adjustment
for genetic and family environmental factors, twin-pair difference values analyses were performed.
Results In all analysis, BMI was associated with UA in men and women. Using the GLMMs, standardized regression coefcients were 0.194 (95 % condence interval:0.0160.373) in men and 0.186 (95 % condence interval:0.0710.302) in women. Considering twin-pair difference value analyses, standardized regression coefcients were0.333 (95 % condence interval: 0.0720.594) in men and0.314 (95 % condence interval: 0.1510.477) in women. Conclusions The present study shows that BMI was signicantly associated with UA, after adjusting for both genetic and familial environment factors in both men and women.
Keywords Twin study Genetics Environment Uric
acid Body mass index
Introduction
The prevalence of high uric acid (UA) levels has increased worldwide in both men and women [13]. In Japan, it has been shown that UA levels in male adolescents have increased during the last...