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ABSTRACT:
The present study deals with the quality control of the Ayurvedic formulation Darvyadi Kvatha Ghana Vati (Tablet) following quality control procedures for the finished product. The results of physico-chemical parameters viz. loss on drying (9.7 %), average weight (5.0 %), friability (0.15 %), disintegration time (85 min) and total phenolics (1.80 %) and disintegration time (85 min) were found. Microbiological limit test and heavy metals Pb, Cd, As, Hg were also found within the limits set by Ayurvedic Pharmacopiea of India (API). The obtained values can be adapted to lay down new pharmacopoeial standards with batch to batch consistency. The phytochemical constituents found in the raw material used for the preparation of Darvyadi Kvatha Ghana Vati (Tablet) facilitate the desirable therapeutic efficacy of the medicinal formulations a whole in elements and also could help in knowing the underlying mechanism of pharmacological action.
KEYWORDS: Ayurvedic formulation, Darvyadi Kvatha Ghana Vati, quality control.
Received on 03.10.2015 Modified on 27.10.2015
Accepted on 18.11.2015 ©A&V Publications All right reserved
Res. J. Pharmacognosy & Phytochem. 7(4): Oct-Dec. 2015; Page 209-213
INTRODUCTION: In the few decades there has been an exponential growth in the field of herbal medicine. It is getting popularized in developing and developed countries owing to its natural origin and lesser side effect. In olden times, vaidyas used to treat patients on individual basis, and prepare drug according to the requirement of the patient. But the scene has changed now; herbal medicines are being manufactured on a large scale in mechanical units, where manufactures come across many problems such as availability of good quality raw materials, authenticated of raw materials, availability of standards, proper standardization methodology of single drugs and formulation, quality control parameters, etc. All these issues were discussed in the paper (Harish and Patel, 2001).
Standards such as identity, purity and potency of single drugs as well as formulations are important regarding therapeutic efficacy of herbal medicines. If the raw materials to be used in a medicine and stage by stage processes of manufacturer standardized the final product namely, the compound formulations (Rastogi et al., 2008; Rathi et al., 2010; Rajput et al., 2012; Tiwari et al., 2013; Tiwari et al., 2014 and Dwivedi et al., 2015) could be expected to conform to...