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This meta-analysis investigated the difference in perceptions of health-related quality of life (HRQOL) among long-term early-stage breast cancer survivors (BCS). The comparison was between African American and European American women. Initial pilot searches suggested that enough studies existed for a meaningful meta-analysis of a BCS population at least 5 years post diagnosis. Only studies using the outcome measure HRQOL were included in the study; this yielded an initial sample of 212 study reports, with 56 reports entering the coding phase of the process. African American women were grossly underrepresented in this set of studies in comparison to the overall breast cancer population. Separate analyses of Medical Outcomes Study 36- Item Short- Form Health Survey, Quality of Life-Cancer Survivor and Quality of Life Index - Cancer Version III instruments were executed. However, no stringent comparison across instruments of the difference between the HRQOL of African American and European American women was possible. When African American women were included in the populations, researchers often did not report their data separately but rather included their data in an overall population and thus differences were masked. The data that were available, including qualitative studies for African American women, suggested that there was a lower perception of the quality of survival in some areas for African American women. These differences suggest the need for greater attention to the physical components of African American BCS. The results point to a need to improve African American participant recruitment in research and to use online databases as a results repository to improve data availability for analysis. Copies of dissertations may be obtained by addressing your request to ProQuest, 789 E. Eisenhower Parkway, P.O. Box 1346, Ann Arbor, MI 48106-1346. Telephone 1-800-521-3042; e-mail: [email protected]