High-risk mesothelioma relation to meteorological and geological condition and distance from naturally occurring asbestos

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Web End = Environ Health Prev Med (2016) 21:8290 DOI 10.1007/s12199-015-0501-3

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Web End = High-risk mesothelioma relation to meteorological and geological condition and distance from naturally occurring asbestos

Abdurrahman Abakay1 Abdullah Cetin Tanrikulu1 Mustafa Ayhan2

Mehmet Sek Imamoglu2 Mahsuk Taylan1 Muhammet Ali Kaplan3

Ozlem Abakay1

Received: 5 October 2015 / Accepted: 27 November 2015 / Published online: 21 December 2015 The Japanese Society for Hygiene 2015

AbstractObjectives Very few studies have investigated the incidence and risk of malignant mesothelioma (MM) associated with distinct sources of asbestos exposure, especially exposure to naturally occurring asbestos (NOA). Methods Subjects were MM, lung, and breast cancer patients who were diagnosed and followed in Diyarbakir Province between 2008 and 2013. The birthplaces of patients were displayed on a geologic map. Geological and meteorological effects on MM were analyzed by logistic regression.

Results A total of 180 MM, 368 breast, and 406 lung cancer patients were included. The median distance from birthplace to ophiolites was 6.26 km for MM, 31.06 km for lung, and 34.31 km for breast cancer (p \ 0.001). The majority of MM cases were seen within 20 km from NOA areas. The MM incidence inside of NOA was 1059/100.000, and out of NOA was 397/100.000; this difference was signicant (p = 0.014). The largest concentration of MM residential areas was within 30 (34 residential areas 36.6 %) of the dominant wind direction. Most MM patients were found in or near the dominant wind direction, especially in the acute angle dened by the dominant wind direction. MM incidence was directly proportional to {[area of NOA (km2)] * [cosine a of wind

direction angle]} and was inversely proportional to the square of the distance (R = 0.291, p = 0.023). Conclusions MM was higher near NOA and in the downwind direction. MM incidence and risk were affected by geological and meteorological factors.

Keywords Mesothelioma Naturally occurring asbestos

Wind direction Incidence Risk

Introduction

Malignant mesothelioma (MM) is a tumor originating from the pleura, although the pericardium, peritoneum, or tunica vaginalis may be affected. The...