Hypercapnia-Induced Changes in Cerebral Blood Flow Against the Background of Experimental Cerebral Circulatory Failure

Abstract

The peculiarities of hypercapnia-induced blood circulatory changes in the local cortical and subcortical regions of the brain and the character of disturbances of the adequate (vasodilator) responses to CO2 were examined on rabbits with experimental chronic cerebral circulatory failure. The study revealed moderation of local vasodilator effect of CO2 and reversal of the circulatory reactions to CO2 manifested in a decrease of local blood fl ow instead of its elevation. The data argue for individual use of carbogen therapy in relation to initial state of the functional organism systems.