Consequences of a high phosphorus intake on mineral metabolism and bone remodeling in dependence of calcium intake in healthy subjects - a randomized placebo-controlled human intervention study

Abstract

The association between elevated plasma phosphate concentrations and cardiovascular morbidity and mortality is well known in patients with chronic kidney disease (CKD) [1]. Nevertheless, in the last years, this association has been shown also for subjects without CKD and phosphate concentrations in the normal range. The Cholesterol And Recurrent Events (CARE) study as well as the Framingham Offspring Study showed a relation between serum phosphate concentrations >1.13 mmol/l and a higher risk for death and cardiovascular events in individuals free of CKD [2, 3]. However, the CARE and the Framingham Offspring Study have not determined the influence of dietary intake on serum phosphate.