Testing flow diversion in animal models: a systematic review

Neuroradiology (2016) 58:375382 DOI 10.1007/s00234-015-1635-0

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Web End = INTERVENTIONAL NEURORADIOLOGY

Testing flow diversion in animal models: a systematic review

Robert Fahed1 & Jean Raymond1,2 & Clina Ducroux1 & Jean-Christophe Gentric2,3 &

Igor Salazkin1 & Daniela Ziegler4 & Guylaine Gevry1 & Tim E. Darsaut5

Received: 16 October 2015 /Accepted: 16 December 2015 /Published online: 8 January 2016 # Springer-Verlag Berlin Heidelberg 2016

AbstractIntroduction Flow diversion (FD) is increasingly used to treat intracranial aneurysms. We sought to systematically review published studies to assess the quality of reporting and summarize the results of FD in various animal models.

Methods Databases were searched to retrieve all animal studies on FD from 2000 to 2015. Extracted data included species and aneurysm models, aneurysm and neck dimensions, type of flow diverter, occlusion rates, and complications. Articles were evaluated using a checklist derived from the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines.

Electronic supplementary material The online version of this article (doi:http://dx.doi.org/10.1007/s00234-015-1635-0

Web End =10.1007/s00234-015-1635- 0) contains supplementary material, which is available to authorized users.

* Jean Raymond [email protected]

1 Centre Hospitalier de lUniversit de Montral (CHUM), ResearchCentre, Interventional Neuroradiology Laboratory, Montreal, Quebec, Canada

2 Centre Hospitalier de lUniversit de Montral (CHUM), Notre-Dame Hospital, Department of Radiology, 1560 Sherbrooke East, Pavilion Simard, Suite Z12909, Montreal, Quebec, Canada H2L 4M1

3 Groupe dtude de la Thrombose en Bretagne Occidentale (GETBO, EA 3878), Brest, France

4 Centre Hospitalier de lUniversit de Montral (CHUM), Direction de lEnseignement et de lAcadmie CHUM|Bibliothque, Montreal, Quebec, Canada

5 Department of Surgery, Division of Neurosurgery, University of Alberta Hospital, Mackenzie Health Sciences Centre, Edmonton, Alberta, Canada

Results Forty-two articles reporting the results of FD in nine different aneurysm models were included. The rabbit elastase-induced aneurysm model was the most commonly used, with 3-month occlusion rates of 73.5 %, (95 %CI [61.982.6 %]). FD of surgical sidewall aneurysms, constructed in rabbits or canines, resulted in high occlusion rates (100 % [65.5 100 %]). FD resulted in modest occlusion rates (15.4 %[8.925.1 %]) when tested in six complex canine aneurysm models designed to reproduce more difficult clinical contexts (large necks, bifurcation, or fusiform aneurysms). Adverse events, including branch...