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EDITOR-The continuing use of nimesulide for Indian children is shocking. 1 Numerous studies have established the life threatening hepatotoxic effects of nimesulide. 2 3 Nimesulide is not used in the United States, and many European countries have also banned the drug because of its unacceptable rate of serious adverse reactions.
Although some studies have indicated that nimesulide may be chosen for osteoarthritis in selected patients with associated gastric problems, other non-steroidal anti-inflammatory drugs such as acetaminophen (paracetamol) are far better choices as antipyretics or analgesics, especially for children. 4 No rationale exists for selecting nimesulide as the first drug of...