Content area
Abstract
Abstract
Bioactive tricyclic quinazolines class of 3,4-dihydro-1H-pyrimido[2,1-b]quinazolin-6(2H)-ones I and 2,3-dihydroimidazo[2,1-b]quinazolin-5(1H)-ones II were synthesized by the formic acid-catalyzed intramolecular cyclization of 3-(2-aminoalkyl)-2-(phenylamino)quinazolin-4(3H)-ones 1 in high yields. A plausible mechanism of the cyclization step is proposed.
Graphical Abstract
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Details
Title
Synthesis of tricyclic quinazolinones via intramolecular cyclization of 3-(2-aminoalkyl)-2-(phenylamino)quinazolin-4(3H)-ones
Author
Yang, Xuhong; Wu, Minghu; Sun, Shaofa; Huang, Changfeng; Guo, Haibing; Wang, Jian; Lee, John; Xing, Yalan
Pages
551-556
Publication year
2016
Publication date
May 2016
ISSN
13811991
e-ISSN
1573501X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1779711906
Copyright
Springer International Publishing Switzerland 2016