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ABSTRACT: Prinzmetal variant angina is an unusual syndrome of cardiac pain. Research recently showed that there is a deficiency in endothelial NO bioactivity at the sites of coronary artery spasm. The aim of this study to investigate that whether is there any relation between serum nitric oxide levels with dietary docosahexaenoic acid, eicosapentaenoic acid and blood pressure in prinzmetal angina patients. A case-control study was conducted on 69 matched pairs, aged 40-60 years, and persons that referred to Emam Khomeini hospital of Ardebil. Participants were interviewed using a structured questionnaire. Venous blood samples were collected from participants. The serum levels of nitric oxide were determined for all participants. Data were analyzed using the Chi-square and Independent sample t-test. The prinzmetal angina patients had higher values for blood pressure. There was no significant difference between groups in serum nitric oxide means. There were significant differences in dietary DHA and EPA between groups. There was significant association between serum nitric oxide and dietary DHA and EPA. Serum NO has significant association with dietary DHA and EPA in prinzmetal angina patients. There wasn't any significant association in serum nitric oxide between groups of study.
KEY WORDS: Blood pressure, Nitric oxide, Omega-3 fatty acids, Prinzmetal angina
INTRODUCTION
Prinzmetal variant angina (PVA) is an unusual syndrome of cardiac pain secondary to myocardial ischemia, which is not intensified by physical exertion or emotional stress, and is associated with transient ST segment elevation (Ruisi et al., 2013). Coronary spasm has an important role in the pathogenesis variant angina (Kusama et al., 2011).Until now pathogenesis of prinzmetal angina (PVA) is not well understood . Studies indicated that the polymorphism of enzyme that produces nitric oxide (NO) is associated with reduced coronary artery spasm in people (Nakayama et al., 2006). Nitric oxide (NO) is a vasodilator and is produced from L-arginine by way of the enzyme NO synthase (Porro et al., 2014). Research recently showed that there is a deficiency in endothelial NO bioactivity at the sites of coronary artery spasm and that this deficiency plays an important role in the pathogenesis of coronary spasm (Qiang et al., 2013). Several studies indicated that short term alternation of blood pressure can stimulate releasing of endothelium derived nitric oxide and this NO can control...